Gelatin-containing
diphtheria-tetanus-pertussis (DTP) vaccine causes sensitization to
gelatin in the recipients.
Kumagai T, Ozaki T,
Kamada M, Igarashi C, Yuri K, Furukawa H, Wagatuma K, Chiba S, Sato M,
Kojima H, Saito A, Okui T, Yano S.
Pediatric Allergy and
Infectious Diseases Society of Sapporo, Kumagai Pediatric Clinic, W-6,
Momijidai, Atsubetsu-ku, 004-0013, Sapporo, Japan.
tkuma@mb.infosnow.ne.jp
Gelatin-specific T cell response was
performed to determine whether a series of vaccinations with
gelatin-containing DTP is a primary sensitization process in gelatin
allergy. Thirty-seven recipients with gelatin-containing DTP who
developed adverse reactions after vaccination and eight recipients of
DTP without gelatin who also developed adverse reactions were studied.
In addition, 10 subjects receiving gelatin-containing vaccine and 10
subjects inoculated with non-gelatin vaccine who did not show any
adverse reactions were also investigated. All subjects inoculated with
gelatin-containing DTP vaccine showed positive T cell responses against
gelatin, however, occurrence of adverse reactions did not correlate with
T cell responses. We conclude that DTP vaccine containing gelatin
induces sensitization to gelatin in the recipients, but the mechanism of
local reactions remains unknown.